The Association of Serum TNF-? Levels and Blood Multi-Elements Modified by TNF-? Gene Polymorphisms in Metal Industrial Workers.

ABSTRACT: Health of the metal industrial workers should be a noteworthy issue due to the hazard ofchronic exposure to metals or toxic elements. The interactions among multiple elements aresophisticated and may differ from person to person. Tumor necrosis factor-? (TNF-?) genepolymorphisms were supposed to be involved with the interactions because TNF-? plays animportant role in inflammation, a mechanism by which toxic elements cause threats to humanhealth. This research aimed to analyze the influence of TNF-? gene polymorphisms and multielementson serum TNF-? level. Blood multi-elements concentrations (lead, cadmium, arsenic,selenium, cobalt, copper, and zinc), serum TNF-? level, and TNF-? single nucleotidepolymorphisms (SNPs), including -238G > A (rs361525), -308G > A (rs1800629), -857C > T(rs1799724), -863C > A (rs1800630), and -1031T > C (rs1799964), were measured in 462 metalindustrial workers. We applied mixed-effect models to analyze the interactions among multielementsand TNF-? SNPs. Blood concentration of all elements were positively associated withserum TNF-? level, and the effects may be modified by TNF-? gene polymorphisms. Our studyrevealed that TNF-? -308A/A and -1031C/C may be susceptible genotypes, and thus we suggestthat those workers should take preventive measures against metal toxicity.

SUBMITTER: Chen TH 

PROVIDER: S-EPMC6862333 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature