Dataset Information

Associations between TNF-? polymorphisms and pneumonia: a meta-analysis.

ABSTRACT:

Background

Several studies evaluated the associations of tumor necrosis factor-? (TNF-?) polymorphisms with pneumonia in different populations. However, the results were conflicting and controversial.

Methods

Databases including PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Data were extracted independently by two investigators. Crude odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated.

Results

Twelve case-control studies and one cohort study were included. Overall, no association between TNF-? -308A/G polymorphism and pneumonia risk was observed for AA +AG vs. GG (OR?=?1.13; 95% CI 0.99-1.30; P?=?0.07). In addition, TNF-? -308A/G polymorphism was not associated with pneumonia mortality (OR?=?1.96; 95% CI 0.94-4.09; P?=?0.07). Furthermore, there was no association of TNF-? -238A/G polymorphism with the risk of pneumonia (OR?=?1.38; 95% CI 0.84-2.28; P?=?0.20).

Conclusions

TNF-? -308A/G, -238A/G polymorphisms were not associated with pneumonia risk. Moreover, TNF-? -308A/G polymorphism did not play a role in the pneumonia mortality risk.

SUBMITTER: Li L

PROVIDER: S-EPMC3620059 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.

Li Li L Nie Wei W Li Weifeng W Yuan Weifeng W Huang Wenjie W

PloS one 20130408 4

<h4>Background</h4>Several studies evaluated the associations of tumor necrosis factor-α (TNF-α) polymorphisms with pneumonia in different populations. However, the results were conflicting and controversial.<h4>Methods</h4>Databases including PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Data were extracted independently by two investigators. Crude odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were ...[more]

PMID: 23577187

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