Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC6863181 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yang Ju J Yan Jing J Shao Jie J Xu Qiuping Q Meng Fanyan F Chen Fangjun F Ding Naiqing N Du Shiyao S Zhou Shujuan S Cai Juan J Wang Qin Q Liu Baorui B
OncoTargets and therapy 20191115
<h4>Background</h4>It was previously reported that targeting vascular epithelial growth factor (VEGF)/VEGFR could modulate the antitumor immunity. VEGFR2 inhibitor YN968D1 is a highly selective VEGFR2 inhibitor and was approved for the treatment of late-stage gastric cancer in 2014, but its role in antitumor immunity remains unknown.<h4>Materials and methods</h4>In this study, we investigated the effects of YN968D1 on the function of T cells in vitro by testing the cytotoxicity and cytokine prod ...[more]