Ontology highlight
ABSTRACT:
SUBMITTER: Tzanavaras PD
PROVIDER: S-EPMC6864522 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20191103 21
A zone-fluidics (ZF) based automated fluorimetric sensor for the determination of pharmaceutically active adamantine derivatives, i.e., amantadine (AMA), memantine (MEM) and rimantadine (RIM) is reported. Discrete zones of the analytes and reagents (<i>o</i>-phthalaldehyde and <i>N</i>-acetylcysteine) mix and react under stopped-flow conditions to yield fluorescent <i>iso</i>-indole derivatives (λ<sub>ex</sub>/ λ<sub>em</sub> = 340/455 nm). The proposed ZF sensor was developed and validated to p ...[more]