Dataset Information

Illusory own body perceptions mapped in the cingulate cortex-An intracranial stimulation study.

ABSTRACT: Body awareness is the result of sensory integration in the posterior parietal cortex; however, other brain structures are part of this process. Our goal is to determine how the cingulate cortex is involved in the representation of our body. We retrospectively selected patients with drug-resistant epilepsy, explored by stereo-electroencephalography, that had the cingulate cortex sampled outside the epileptogenic zone. The clinical effects of high-frequency electrical stimulation were reviewed and only those sites that elicited changes related to body perception were included. Connectivity of the cingulate cortex and other cortical structures was assessed using the h² coefficient, following a nonlinear regression analysis of the broadband EEG signal. Poststimulation changes in connectivity were compared between two sets of stimulations eliciting or not eliciting symptoms related to body awareness (interest and control groups). We included 17 stimulations from 12 patients that reported different types of body perception changes such as sensation of being pushed toward right/left/up, one limb becoming heavier/lighter, illusory sensation of movement, sensation of pressure, sensation of floating or detachment of one hemi-body. High-frequency stimulation in the cingulate cortex (1 anterior, 15 middle, 1 posterior part) elicits body perception changes, associated with a decreased connectivity of the dominant posterior insula and increased coupling between other structures, located particularly in the nondominant hemisphere.

SUBMITTER: Popa I

PROVIDER: S-EPMC6865384 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Illusory own body perceptions mapped in the cingulate cortex-An intracranial stimulation study.

Popa Irina I Barborica Andrei A Scholly Julia J Donos Cristian C Bartolomei Fabrice F Lagarde Stanislas S Hirsch Edouard E Valenti-Hirsch Maria-Paola MP Maliia Mihai Dragos MD Arbune Anca Adriana AA Daneasa Andrei A Ciurea Jean J Bajenaru Ovidiu-Alexandru OA Mindruta Ioana I

Human brain mapping 20190313 9

Body awareness is the result of sensory integration in the posterior parietal cortex; however, other brain structures are part of this process. Our goal is to determine how the cingulate cortex is involved in the representation of our body. We retrospectively selected patients with drug-resistant epilepsy, explored by stereo-electroencephalography, that had the cingulate cortex sampled outside the epileptogenic zone. The clinical effects of high-frequency electrical stimulation were reviewed and ...[more]

PMID: 30868705

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Project description:The subjective and behavioral effects of intracranial electrical stimulation (iES) have been studied for decades, but there is a knowledge gap regarding the relationship between the magnitude of electric current and the type, intensity and valence of evoked subjective experiences. We report on rare iES data from 18 neurosurgical patients with implanted intracranial electrodes in the orbitofrontal cortex (OFC), the insula (INS) and the anterior portion of cingulate cortex (ACC). ACC stimulation elicited somatic and visceral sensations, whereas OFC stimulation predominantly elicited olfactory and gustatory responses, and INS stimulation elicited a mix of effects involving somatic and visceral sensations, olfaction and gustation. Further, we found striking evidence that the magnitude of electric current delivered intracranially correlated positively with the perceived intensity of subjective experience and the evoked emotional state, a relationship observed across all three regions. Finally, we observed that the majority of reported experiences were negatively valenced and unpleasant, especially those elicited by ACC stimulation. The present study provides novel case studies from the human brain confirming that these structures contribute causally to the creation of affective states and demonstrates a direct relationship between the magnitude of electrical stimulation of these structures and the qualia of elicited subjective experience. Summary: This study provides critical knowledge about the effect of electrical charge magnitude on the intensity of human subjective experiences and emotional states. We shed light on the fundamental relationship between the electrical (physical) state of cortical tissue and the modality and intensity of human (subjective) experience. As electroceutical interventions are increasingly employed to treat neurological and psychiatric disorders, these findings highlight the importance of electrical stimulation magnitude for eliciting specific changes in human subjective experience.

Dataset Information

Illusory own body perceptions mapped in the cingulate cortex-An intracranial stimulation study.

Publications

Illusory own body perceptions mapped in the cingulate cortex-An intracranial stimulation study.

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