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Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI.

ABSTRACT: Age-related hearing loss (HL) can be related to brain dysfunction or structural damage and may result in cerebral metabolic/perfusion abnormalities. Arterial spin labeling (ASL) magnetic resonance imaging (MRI) allows investigating noninvasively brain perfusion changes. Pseudocontinuous ASL and T1-weighted MRI (at 3 T) and neuropsychological testing (Montreal Cognitive Assessment) were performed in 31 HL (age range?=?47-77 years, mean age?±?SD = 63.4?±?8.4?years, pure-tone average [PTA] HL?>?50?dB) and 28 normal hearing (NH; age range?=?48-78 years, mean age?±?SD?=?59.7?±?7.4?years) subjects. Cerebral blood flow (CBF) and gray matter volume (GMV) were analyzed in the cortical volume to assess perfusion and structural group differences. Two HL subjects showing cognitive impairment were excluded from group comparisons. No significant differences in either global or local atrophy were detected between groups but the HL group exhibited significant regional effects of reduced perfusion within the bilateral primary auditory cortex, with maximal CBF difference (-17.2%) in the right lateral Heschl's gyrus. For the whole sample of HL and NH subjects (n?=?59?=?31 HL?+?28 NH), the regional CBF was correlated positively to the regional GMV (p?=?0.020). In HL subjects (n?=?31), the regional CBF was correlated negatively to the audiogram steepness (frequency range: 2-4 kHz, right ear: p?=?0.022, left ear: p?=?0.015). The observed cortical pattern of perfusion reduction suggests that neuronal metabolism can be related to HL before the recognition of brain structural damage. This also illustrates the potential of ASL-MRI to contribute early functional markers of reduced central processing associated with HL.

SUBMITTER: Ponticorvo S

PROVIDER: S-EPMC6865742 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI.

Ponticorvo Sara S Manara Renzo R Pfeuffer Josef J Cappiello Arianna A Cuoco Sofia S Pellecchia Maria Teresa MT Saponiero Renato R Troisi Donato D Cassandro Claudia C John Marta M Scarpa Alfonso A Cassandro Ettore E Di Salle Francesco F Esposito Fabrizio F

Human brain mapping 20190204 8

Age-related hearing loss (HL) can be related to brain dysfunction or structural damage and may result in cerebral metabolic/perfusion abnormalities. Arterial spin labeling (ASL) magnetic resonance imaging (MRI) allows investigating noninvasively brain perfusion changes. Pseudocontinuous ASL and T1-weighted MRI (at 3 T) and neuropsychological testing (Montreal Cognitive Assessment) were performed in 31 HL (age range = 47-77 years, mean age ± SD = 63.4 ± 8.4 years, pure-tone average [PTA] HL > 50 ...[more]

PMID: 30715769

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Project description:BACKGROUND:With the disappointing outcomes of clinical trials on patients with Alzheimer's disease or mild cognitive impairment (MCI), there is increasing attention to understanding cognitive decline in normal elderly individuals, with the goal of identifying subjects who are most susceptible to imminent cognitive impairment. PURPOSE/HYPOTHESIS:To evaluate the potential of cerebral blood flow (CBF) as a biomarker by investigating the relationship between CBF at baseline and cognition at follow-up. STUDY TYPE:Prospective longitudinal study with a 4-year time interval. POPULATION:309 healthy subjects aged 20-89 years old. FIELD STRENGTH/SEQUENCE:3T pseudo-continuous-arterial-spin-labeling MRI. ASSESSMENT:CBF at baseline and cognitive assessment at both baseline and follow-up. STATISTICAL TESTS:Linear regression analyses with age, systolic blood pressure, physical activity, and baseline cognition as covariates. RESULTS:Linear regression analyses revealed that whole-brain CBF at baseline was predictive of general fluid cognition at follow-up. This effect was observed in the older group (age ?54 years, ??=?0.221, P?=?0.004), but not in younger or entire sample (??=?0.018, P?=?0.867 and ??=?0.089, P?=?0.098, respectively). Among major brain lobes, frontal CBF had the highest sensitivity in predicting future cognition, with a significant effect observed for fluid cognition (??=?0.244 P?=?0.001), episodic memory (??=?0.294, P?=?0.001), and reasoning (??=?0.186, P?=?0.027). These associations remained significant after accounting for baseline cognition. Voxelwise analysis revealed that medial frontal cortex and anterior cingulate cortex, part of the default mode network (DMN), are among the most important regions in predicting fluid cognition. DATA CONCLUSION:In a healthy aging cohort, CBF can predict general cognitive ability as well as specific domains of cognitive function. LEVEL OF EVIDENCE:1 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2018;48:449-458.

Dataset Information

Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI.

Publications

Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI.

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