Dataset Information

Precuneus degeneration in nondemented elderly individuals with APOE ?4: Evidence from structural and functional MRI analyses.

ABSTRACT: Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ?4 allele imparts a high genetic risk of developing AD. Whether the APOE ?4 allele damages the brain when cognitive functions are still intact is important to understand, especially for possible early detection and intervention. This study aimed to examine the selective degeneration pattern associated with the APOE ?4 allele in the brains of cognitively normal elderly subjects. We enrolled 35 cognitively healthy ?4 carriers and 40 non-carriers (53 to 81 years old) to evaluate group differences in cortical thickness and brain activation during a memory-encoding task. We also assessed the functional connectivity of the brain regions with both structural and functional damages. The results from the neuropsychological tests showed that the performances of ?4 carriers and non-carriers were comparable. Primarily, we found that the precuneus exhibited thinner cortical thickness and decreased deactivation during memory encoding. Furthermore, the connectivity analyses show that carriers exhibited damaged connectivity of the precuneus to several regions in the default mode network and the attention/executive control network. Our study reveals the degeneration pattern of the ?4 allele, which could be used as a potential biomarker for early detection for possible interventions and treatments. Hum Brain Mapp 38:271-282, 2017. © 2016 Wiley Periodicals, Inc.

SUBMITTER: Chen Y

PROVIDER: S-EPMC6866889 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Precuneus degeneration in nondemented elderly individuals with APOE ɛ4: Evidence from structural and functional MRI analyses.

Chen Yaojing Y Liu Zhen Z Zhang Junying J Chen Kewei K Yao Li L Li Xin X Gong Gaolang G Wang Jun J Zhang Zhanjun Z

Human brain mapping 20160904 1

Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ɛ4 allele imparts a high genetic risk of developing AD. Whether the APOE ɛ4 allele damages the brain when cognitive functions are still intact is important to understand, especially for possible early detection and intervention. This study aimed to examine the selective degeneration pattern associated with the APOE ɛ4 allele in the bra ...[more]

PMID: 27593520

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Project description:Recent studies show that cerebral ?-amyloid (A?) deposition is associated with blood pressure and measures of arterial stiffness in nondemented individuals.To examine the association between measures of arterial stiffness and change in A? deposition over time.Deposition of A? was determined in a longitudinal observational study of aging by positron emission tomography using the Pittsburgh compound B twice 2 years apart in 81 nondemented individuals 83 years and older. Arterial stiffness was measured with a noninvasive and automated waveform analyzer at the time closest to the second positron emission tomography scan. All measures were performed under standardized conditions. Pulse wave velocity (PWV) was measured in the central (carotid-femoral and heart-femoral PWV), peripheral (femoral-ankle PWV), and mixed (brachial-ankle PWV) vascular beds.The change in A? deposition over 2 years was calculated from the 81 individuals with repeat A?-positron emission tomography.The proportion of A?-positive individuals increased from 48% at baseline to 75% at follow-up. Brachial-ankle PWV was significantly higher among A?-positive participants at baseline and follow-up. Femoral-ankle PWV was only higher among A?-positive participants at follow-up. Measures of central stiffness and blood pressure were not associated with A? status at baseline or follow-up, but central stiffness was associated with a change in A? deposition over time. Each standard deviation increase in central stiffness (carotid-femoral PWV, P?=?.001; heart-femoral PWV, P?=?.004) was linked with increases in A? deposition over 2 years.This study showed that A? deposition increases with age in nondemented individuals and that arterial stiffness is strongly associated with the progressive deposition of A? in the brain, especially in this age group. The association between A? deposition changes over time and generalized arterial stiffness indicated a relationship between the severity of subclinical vascular disease and progressive cerebral A? deposition.

Dataset Information

Precuneus degeneration in nondemented elderly individuals with APOE ?4: Evidence from structural and functional MRI analyses.

Publications

Precuneus degeneration in nondemented elderly individuals with APOE ɛ4: Evidence from structural and functional MRI analyses.

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