Chromatinization of Escherichia coli with archaeal histones.
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ABSTRACT:
SUBMITTER: Rojec M
PROVIDER: S-EPMC6867714 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Chromatinization of <i>Escherichia coli</i> with archaeal histones.
Rojec Maria M Hocher Antoine A Stevens Kathryn M KM Merkenschlager Matthias M Warnecke Tobias T
eLife 20191106
Nucleosomes restrict DNA accessibility throughout eukaryotic genomes, with repercussions for replication, transcription, and other DNA-templated processes. How this globally restrictive organization emerged during evolution remains poorly understood. Here, to better understand the challenges associated with establishing globally restrictive chromatin, we express histones in a naive system that has not evolved to deal with nucleosomal structures: <i>Escherichia coli</i>. We find that histone prot ...[more]
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