Ontology highlight
ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC6868014 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yu Yangyang Y Jia Wenwen W Lyu Yao Y Su Dingwen D Bai Mingliang M Shen Junwei J Qiao Jing J Han Tong T Liu Wenqiang W Chen Jiayu J Chen Wen W Ye Dan D Guo Xudong X Zhu Songcheng S Xi Jiajie J Zhu Ruixin R Wan Xiaoping X Gao Shaorong S Zhu Jiyue J Kang Jiuhong J
Cell discovery 20191105
Telomere maintenance is critical for chromosome stability. Here we report that periodic tryptophan protein 1 (PWP1) is involved in regulating telomere length homeostasis. <i>Pwp1</i> appears to be essential for mouse development and embryonic stem cell (ESC) survival, as homozygous <i>Pwp1</i>-knockout mice and ESCs have never been obtained. Heterozygous <i>Pwp1</i>-knockout mice had shorter telomeres and decreased reproductive capacity. <i>Pwp1</i> depletion induced rapid telomere shortening ac ...[more]