Ontology highlight
ABSTRACT:
SUBMITTER: Bilsland AE
PROVIDER: S-EPMC6700475 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Bilsland Alan E AE Liu Yu Y Turnbull Andrew A Sumpton David D Stevenson Katrina K Cairney Claire J CJ Boyd Susan M SM Roffey Jon J Jenkinson David D Keith W Nicol WN
Neoplasia (New York, N.Y.) 20190808 9
Telomere signaling and metabolic dysfunction are hallmarks of cell aging. New agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. We report identification and characterization of a pyrazolopyrimidine compound series identified from screens focused on cell immortality and whose targets are glycolytic kinase PGK1 and oxidative stress sensor DJ1. We performed structure-activity studies on the series to develop ...[more]