AMPA receptors in the synapse turnover by monomer diffusion.
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ABSTRACT:
SUBMITTER: Morise J
PROVIDER: S-EPMC6868016 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
AMPA receptors in the synapse turnover by monomer diffusion.
Morise Jyoji J Suzuki Kenichi G N KGN Kitagawa Ayaka A Wakazono Yoshihiko Y Takamiya Kogo K Tsunoyama Taka A TA Nemoto Yuri L YL Takematsu Hiromu H Kusumi Akihiro A Oka Shogo S
Nature communications 20191120 1
The number and subunit compositions of AMPA receptors (AMPARs), hetero- or homotetramers composed of four subunits GluA1-4, in the synapse is carefully tuned to sustain basic synaptic activity. This enables stimulation-induced synaptic plasticity, which is central to learning and memory. The AMPAR tetramers have been widely believed to be stable from their formation in the endoplasmic reticulum until their proteolytic decomposition. However, by observing GluA1 and GluA2 at the level of single mo ...[more]
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