Ontology highlight
ABSTRACT:
SUBMITTER: Almeida CF
PROVIDER: S-EPMC6868179 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Almeida Catarina F CF Sundararaj Srinivasan S Le Nours Jérôme J Praveena T T Cao Benjamin B Burugupalli Satvika S Smith Dylan G M DGM Patel Onisha O Brigl Manfred M Pellicci Daniel G DG Williams Spencer J SJ Uldrich Adam P AP Godfrey Dale I DI Rossjohn Jamie J
Nature communications 20191120 1
Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an understanding of the antigen reactivity and function of type I NKT cells, our knowledge of type II NKT cells in health and disease remains unclear. Here we describe a population of type II NKT cells that recognise and respond to the microbial antigen, α-glucuronosyl-diacylglycerol (α-GlcADAG) presented by CD1d, but not the prototypical type I NKT cell agonist, α-galactos ...[more]