Dataset Information

Correlation between Tafel Analysis and Electrochemical Impedance Spectroscopy by Prediction of Amperometric Response from EIS.

ABSTRACT: Tafel analysis and electrochemical impedance spectroscopy (EIS) have been widely used to characterize many kinds of electrocatalysts. The former provides the kinetic information of an electrochemical reaction with the exchange current while the latter does with the charge transfer resistance closely related to the exchange current. Both techniques, however, suffer from practical troubles which often decrease their reliabilities. In order to circumvent those troubles, an alternative was suggested that Tafel analysis was combined with EIS, even though its theoretical background was not clearly established. Tafel analysis is based on dc measurement, and EIS is on an ac one, respectively. Here, inspired by the second generation of EIS from chronoamperometry, we try to find how those techniques are correlated by investigating an amperometric response from EIS. The first step is Fourier transform of an arbitrary dc potential signal in the time domain to obtain the amplitudes and phases of the Fourier series which are equivalent to ac signals of each frequency. Second, with the Fourier series being applied onto the impedance data, the responding currents of each frequency are calculated by Ohm's law. Third, the current in the frequency domain is transferred back to the time domain by inverse Fourier transform to yield chronoamperometric or Tafel plots depending on the type of the applied dc potential. Finally, we can study Tafel plots based on EIS at different conditions and their correlations which are expected to be a better indicator for characterizing electrocatalysts instead of the slope of the classical Tafel analysis.

SUBMITTER: Park K

PROVIDER: S-EPMC6868906 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Correlation between Tafel Analysis and Electrochemical Impedance Spectroscopy by Prediction of Amperometric Response from EIS.

Park Kyungsoon K Chang Byoung-Yong BY Hwang Seongpil S

ACS omega 20191108 21

Tafel analysis and electrochemical impedance spectroscopy (EIS) have been widely used to characterize many kinds of electrocatalysts. The former provides the kinetic information of an electrochemical reaction with the exchange current while the latter does with the charge transfer resistance closely related to the exchange current. Both techniques, however, suffer from practical troubles which often decrease their reliabilities. In order to circumvent those troubles, an alternative was suggested ...[more]

PMID: 31763554

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Project description:In the last decade, researchers have been searching for innovative platforms, methods, and techniques able to address recurring problems with the current cancer detection methods. Early disease detection, fast results, point-of-care sensing, and cost are among the most prevalent issues that need further exploration in this field. Herein, studies are focused on overcoming these problems by developing an electrochemical device able to detect telomerase as a cancer biomarker. Electrochemical platforms and techniques are more appealing for cancer detection, offering lower costs than the established cancer detection methods, high sensitivity inherent to the technique, rapid signal processing, and their capacity of being miniaturized. Therefore, Au interdigital electrodes and electrochemical impedance spectroscopy were used to detect telomerase activity in acute T cell leukemia. Different cancer cell concentrations were evaluated, and a detection limit of 1.9 × 105 cells/mL was obtained. X-ray photoelectron spectroscopy was used to characterize the telomerase substrate (TS) DNA probe self-assembled monolayer on gold electrode surfaces. Atomic force microscopy displayed three-dimensional images of the surface to establish a height difference of 9.0 nm between the bare electrode and TS-modified Au electrodes. The TS probe is rich in guanines, thus forming secondary structures known as G-quadruplex that can be triggered with a fluorescence probe. Confocal microscopy fluorescence images showed the formation of DNA G-quadruplex because of TS elongation by telomerase on the Au electrode surface. Moreover, electrodes exposed to telomerase containing 2',3'-dideoxyguanosine-5'-triphosphate (ddGTP) did not exhibit high fluorescence, as ddGTP is a telomerase inhibitor, thus making this device suitable for telomerase inhibitors capacity studies. The electrochemical method and Au microchip device may be developed as a biosensor for a point-of-care medical device.

Dataset Information

Correlation between Tafel Analysis and Electrochemical Impedance Spectroscopy by Prediction of Amperometric Response from EIS.

Publications

Correlation between Tafel Analysis and Electrochemical Impedance Spectroscopy by Prediction of Amperometric Response from EIS.

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