A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus.
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ABSTRACT:
SUBMITTER: de Hollander G
PROVIDER: S-EPMC6869470 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus.
de Hollander Gilles G Keuken Max C MC Bazin Pierre-Louis PL Weiss Marcel M Neumann Jane J Reimann Katja K Wähnert Miriam M Turner Robert R Forstmann Birte U BU Schäfer Andreas A
Human brain mapping 20140304 9
The subthalamic nucleus (STN) is an important node of the cortico-basal ganglia network and the main target of deep brain stimulation (DBS) in Parkinson's disease. Histological studies have revealed an inhomogeneous iron distribution within the STN, which has been related to putative subdivisions within this nucleus. Here, we investigate the iron distribution in more detail using quantitative susceptibility mapping (QSM), a novel magnetic resonance imaging (MRI) contrast mechanism. QSM allows fo ...[more]
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