Reduced cerebellar gray matter is a neural signature of physical frailty.
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ABSTRACT:
SUBMITTER: Chen WT
PROVIDER: S-EPMC6869536 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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Reduced cerebellar gray matter is a neural signature of physical frailty.
Chen Wei-Ta WT Chou Kun-Hsien KH Liu Li-Kuo LK Lee Pei-Lin PL Lee Wei-Ju WJ Chen Liang-Kung LK Wang Pei-Ning PN Lin Ching-Po CP
Human brain mapping 20150619 9
Physical frailty has been recognized as a clinical syndrome resulting from declines in various physiological systems; however, the role of the central nervous system in the pathophysiology of frailty remains unclear. The I-Lan Longitudinal Aging Study randomly sampled community-dwelling people aged 50 or older for a brain magnetic resonance imaging study. All participants were assessed for frailty status (robust, prefrail, and frail) based on the presence of five frailty components: slow walking ...[more]
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