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Sensing of citrulline modifications in histone peptides by deep cavitand hosts.

ABSTRACT: Arrayed cavitand:fluorophore sensor complexes can selectively sense small citrulline modifications at arginine residues on post-translationally modified peptides. The sensor can differentiate between different numbers of citrulline modifications, and a simple two-fluorophore, 6-component array can effect cross-reactive discrimination between single modifications in aqueous solution.

SUBMITTER: Gill AD

PROVIDER: S-EPMC6872487 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Sensing of citrulline modifications in histone peptides by deep cavitand hosts.

Gill Adam D AD Hickey Briana L BL Wang Siwen S Xue Min M Zhong Wenwan W Hooley Richard J RJ

Chemical communications (Cambridge, England) 20191001 88

Arrayed cavitand:fluorophore sensor complexes can selectively sense small citrulline modifications at arginine residues on post-translationally modified peptides. The sensor can differentiate between different numbers of citrulline modifications, and a simple two-fluorophore, 6-component array can effect cross-reactive discrimination between single modifications in aqueous solution. ...[more]

PMID: 31621759

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