Ontology highlight
ABSTRACT:
SUBMITTER: Levet S
PROVIDER: S-EPMC6872510 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Levet Sandrine S Charvet B B Bertin A A Deschaumes A A Perron H H Hober D D
Current diabetes reports 20191121 12
<h4>Purpose of the review</h4>The aim of this review is to discuss recent data pointing at an involvement of human endogenous retroviruses (HERVs) in type 1 diabetes (T1D) onset and progression.<h4>Recent findings</h4>The envelope protein of HERV-W family, named HERV-W-Env, was detected in pancreata from T1D patients and was shown to display pro-inflammatory properties and direct toxicity toward pancreatic beta cells. The etiopathogenesis of T1D remains elusive, even if conventional environmenta ...[more]