Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Bravo V
PROVIDER: S-EPMC6150493 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Rodriguez-Bravo Veronica V Pippa Raffaella R Song Won-Min WM Carceles-Cordon Marc M Dominguez-Andres Ana A Fujiwara Naoto N Woo Jungreem J Koh Anna P AP Ertel Adam A Lokareddy Ravi K RK Cuesta-Dominguez Alvaro A Kim Rosa S RS Rodriguez-Fernandez Irene I Li Peiyao P Gordon Ronald R Hirschfield Hadassa H Prats Josep M JM Reddy E Premkumar EP Fatatis Alessandro A Petrylak Daniel P DP Gomella Leonard L Kelly W Kevin WK Lowe Scott W SW Knudsen Karen E KE Galsky Matthew D MD Cingolani Gino G Lujambio Amaia A Hoshida Yujin Y Domingo-Domenech Josep J
Cell 20180809 5
Nuclear pore complexes (NPCs) regulate nuclear-cytoplasmic transport, transcription, and genome integrity in eukaryotic cells. However, their functional roles in cancer remain poorly understood. We interrogated the evolutionary transcriptomic landscape of NPC components, nucleoporins (Nups), from primary to advanced metastatic human prostate cancer (PC). Focused loss-of-function genetic screen of top-upregulated Nups in aggressive PC models identified POM121 as a key contributor to PC aggressive ...[more]