Dataset Information

Current Opinions and Consensus for Studying Tremor in Animal Models.

ABSTRACT: Tremor is the most common movement disorder; however, we are just beginning to understand the brain circuitry that generates tremor. Various neuroimaging, neuropathological, and physiological studies in human tremor disorders have been performed to further our knowledge of tremor. But, the causal relationship between these observations and tremor is usually difficult to establish and detailed mechanisms are not sufficiently studied. To overcome these obstacles, animal models can provide an important means to look into human tremor disorders. In this manuscript, we will discuss the use of different species of animals (mice, rats, fruit flies, pigs, and monkeys) to model human tremor disorders. Several ways to manipulate the brain circuitry and physiology in these animal models (pharmacology, genetics, and lesioning) will also be discussed. Finally, we will discuss how these animal models can help us to gain knowledge of the pathophysiology of human tremor disorders, which could serve as a platform towards developing novel therapies for tremor.

SUBMITTER: Kuo SH

PROVIDER: S-EPMC6872927 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

Current Opinions and Consensus for Studying Tremor in Animal Models.

Kuo Sheng-Han SH Louis Elan D ED Faust Phyllis L PL Handforth Adrian A Chang Su-Youne SY Avlar Billur B Lang Eric J EJ Pan Ming-Kai MK Miterko Lauren N LN Brown Amanda M AM Sillitoe Roy V RV Anderson Collin J CJ Pulst Stefan M SM Gallagher Martin J MJ Lyman Kyle A KA Chetkovich Dane M DM Clark Lorraine N LN Tio Murni M Tan Eng-King EK Elble Rodger J RJ

Cerebellum (London, England) 20191201 6

Tremor is the most common movement disorder; however, we are just beginning to understand the brain circuitry that generates tremor. Various neuroimaging, neuropathological, and physiological studies in human tremor disorders have been performed to further our knowledge of tremor. But, the causal relationship between these observations and tremor is usually difficult to establish and detailed mechanisms are not sufficiently studied. To overcome these obstacles, animal models can provide an impor ...[more]

PMID: 31124049

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Dataset Information

Current Opinions and Consensus for Studying Tremor in Animal Models.

Publications

Current Opinions and Consensus for Studying Tremor in Animal Models.

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