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Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies.

ABSTRACT: BACKGROUND:Dyslexia and Attention-deficit/hyperactivity disorder (ADHD) are highly comorbid neurodevelopmental disorders (estimates of 25-40% bidirectional comorbidity). Previous work has identified strong genetic and cognitive overlap between the disorders, but neural overlap is relatively unexplored. This study is a systematic meta-analysis of existing voxel-based morphometry studies to determine whether there is any overlap in the gray matter correlates of both disorders. METHODS:We conducted anatomic likelihood estimate (ALE) meta-analyses of voxel-based morphometry studies in which individuals with dyslexia (15 studies; 417 cases, 416 controls) or ADHD (22 studies; 898 cases, 763 controls) were compared to typically developing controls. We generated ALE maps for dyslexia vs. controls and ADHD vs. controls using more conservative (p?

SUBMITTER: McGrath LM

PROVIDER: S-EPMC6873566 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies.

McGrath Lauren M LM Stoodley Catherine J CJ

Journal of neurodevelopmental disorders 20191121 1

<h4>Background</h4>Dyslexia and Attention-deficit/hyperactivity disorder (ADHD) are highly comorbid neurodevelopmental disorders (estimates of 25-40% bidirectional comorbidity). Previous work has identified strong genetic and cognitive overlap between the disorders, but neural overlap is relatively unexplored. This study is a systematic meta-analysis of existing voxel-based morphometry studies to determine whether there is any overlap in the gray matter correlates of both disorders.<h4>Methods</ ...[more]

PMID: 31752659

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