Ontology highlight
ABSTRACT:
SUBMITTER: Acebron I
PROVIDER: S-EPMC6873925 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Acebrón Iván I Mahasenan Kiran V KV De Benedetti Stefania S Lee Mijoon M Artola-Recolons Cecilia C Hesek Dusan D Wang Huan H Hermoso Juan A JA Mobashery Shahriar S
Journal of the American Chemical Society 20170510 20
The N-acetylglucosaminidase NagZ of Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, cell-wall-derived natural products. This reaction regulates gene expression for the β-lactam resistance enzyme, β-lactamase. The enzyme catalyzes hydrolysis of N-acetyl-β-d-glucosamine-(1→4)-1,6-anhydro-N-acetyl-β-d-muramyl-peptide (1) to N-acetyl-β-d-glucosamine (2) and 1,6-anhydro-N-acetyl-β-d-muramyl-peptide (3). The structural and functional aspects of catalysis by Na ...[more]