Ontology highlight
ABSTRACT:
SUBMITTER: Majidi SP
PROVIDER: S-EPMC6874310 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Majidi Shahriyar P SP Reddy Naveen C NC Moore Michael J MJ Chen Hao H Yamada Tomoko T Andzelm Milena M MM Cherry Timothy J TJ Hu Linda S LS Greenberg Michael E ME Bonni Azad A
Cell reports 20191101 7
Compensation among paralogous transcription factors (TFs) confers genetic robustness of cellular processes, but how TFs dynamically respond to paralog depletion on a genome-wide scale in vivo remains incompletely understood. Using single and double conditional knockout of myocyte enhancer factor 2 (MEF2) family TFs in granule neurons of the mouse cerebellum, we find that MEF2A and MEF2D play functionally redundant roles in cerebellar-dependent motor learning. Although both TFs are highly express ...[more]