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Pd-catalyzed arylation of linear and angular spirodiamine salts under aerobic conditions.

ABSTRACT: Application of Buchwald-Hartwig catalysis for development of biologically relevant arylspirodiamine compounds is reported. This synthetic methodology requires no inert atmosphere and affords yields up to 93% in just 20 min. Linear and sterically hindered angular spirodiamines in salt and free-base form are coupled with electron-rich and -withdrawing aryl chlorides, demonstrating a broad scope and applicability of this protocol.

SUBMITTER: Reilly SW

PROVIDER: S-EPMC6874415 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Pd-catalyzed arylation of linear and angular spirodiamine salts under aerobic conditions.

Reilly Sean W SW Bryan Nikaela W NW Mach Robert H RH

Tetrahedron letters 20161223 5

Application of Buchwald-Hartwig catalysis for development of biologically relevant arylspirodiamine compounds is reported. This synthetic methodology requires no inert atmosphere and affords yields up to 93% in just 20 min. Linear and sterically hindered angular spirodiamines in salt and free-base form are coupled with electron-rich and -withdrawing aryl chlorides, demonstrating a broad scope and applicability of this protocol. ...[more]

PMID: 31762498

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