The structural biology of the dynamin-related proteins: New insights into a diverse, multitalented family.
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ABSTRACT:
SUBMITTER: Ford MGJ
PROVIDER: S-EPMC6876869 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
The structural biology of the dynamin-related proteins: New insights into a diverse, multitalented family.
Ford Marijn G J MGJ Chappie Joshua S JS
Traffic (Copenhagen, Denmark) 20190826 10
Dynamin-related proteins are multidomain, mechanochemical GTPases that self-assemble and orchestrate a wide array of cellular processes. Over the past decade, structural insights from X-ray crystallography and cryo-electron microscopy have reshaped our mechanistic understanding of these proteins. Here, we provide a historical perspective on these advances that highlights the structural attributes of different dynamin family members and explores how these characteristics affect GTP hydrolysis, co ...[more]
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