Ontology highlight
ABSTRACT:
SUBMITTER: Nikolaienko RM
PROVIDER: S-EPMC3478258 | biostudies-literature | 2012 Jul-Aug
REPOSITORIES: biostudies-literature
Nikolaienko Roman M RM Agyekum Boadi B Bouyain Samuel S
Cell adhesion & migration 20120701 4
There is general agreement that many cancers are associated with aberrant phosphotyrosine signaling, which can be caused by the inappropriate activities of tyrosine kinases or tyrosine phosphatases. Furthermore, incorrect activation of signaling pathways has been often linked to changes in adhesion events mediated by cell surface receptors. Among these receptors, receptor protein tyrosine phosphatases (RPTPs) both antagonize tyrosine kinases as well as engage extracellular ligands. A recent weal ...[more]