Manganese homeostasis: from rare single-gene disorders to complex phenotypes and diseases.
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ABSTRACT:
SUBMITTER: Katz N
PROVIDER: S-EPMC6877306 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Manganese homeostasis: from rare single-gene disorders to complex phenotypes and diseases.
Katz Nathan N Rader Daniel J DJ
The Journal of clinical investigation 20191201 12
Manganese (Mn) participates in a variety of distinct physiological processes, including acting as a cofactor for several enzymes and metalloenzymes, in addition to playing a role in immune function, endocrine function, hematopoiesis, and oxidative stress regulation. Mn homeostasis is tightly regulated via intestinal absorption and hepatobiliary and intestinal excretion. In this issue of the JCI, Mercadante and colleagues explored the role of the metal transporter Slc30a10 in vivo using a mouse m ...[more]
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