Gastric mucosal devitalization (GMD): translation to a novel endoscopic metabolic therapy.

ABSTRACT: Background and study aims  The metabolic effects of bariatric surgery may partially result from removal of the gastric mucosa, an often underappreciated endocrine organ. Using argon plasma coagulation (APC), we may be able to selectively devitalize (ablate) the mucosa. The aim of this study was to identify the optimal tissue color that would correspond to selective gastric mucosal devitalization (GMD) using ex-vivo human stomach specimens. Patients and methods  Stomach specimens were obtained at sleeve gastrectomy. Prior to APC application, a submucosal fluid cushion was created. APC was then applied over a 2 × 2-cm area to the fundus and body, aiming for the three indicator colors (white, golden, brown). Pathological analysis was then performed independently and in a blinded

SUBMITTER: Fayad L 

PROVIDER: S-EPMC6877422 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature