Ontology highlight
ABSTRACT:
SUBMITTER: Ashfaq-Khan M
PROVIDER: S-EPMC6877510 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Ashfaq-Khan Muhammad M Aslam Misbah M Qureshi Muhammad Asif MA Senkowski Marcel Sascha MS Yen-Weng Shih S Strand Susanne S Kim Yong Ook YO Pickert Geethanjali G Schattenberg Jörn M JM Schuppan Detlef D
Scientific reports 20191125 1
We previously demonstrated that a common dietary protein component, wheat amylase trypsin inhibitors (ATI), stimulate intestinal macrophages and dendritic cells via toll like receptor 4. Activation of these intestinal myeloid cells elicits an inflammatory signal that is propagated to mesenteric lymph nodes, and that can facilitate extraintestinal inflammation. Mice were fed a well-defined high fat diet, with (HFD/ATI) or without (HFD) nutritionally irrelevant amounts of ATI. Mice on HFD/ATI deve ...[more]