Ontology highlight
ABSTRACT:
SUBMITTER: Okada H
PROVIDER: S-EPMC6878047 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Okada Hirokazu H Yagi Ryohei R Gardeux Vincent V Deplancke Bart B Hafen Ernst E
Molecular systems biology 20191101 11
Size of organs/organisms is a polygenic trait. Many of the growth-regulatory genes constitute conserved growth signaling pathways. However, how these multiple genes are orchestrated at the systems level to attain the natural variation in size including sexual size dimorphism is mostly unknown. Here we take a multi-layered systems omics approach to study size variation in the Drosophila wing. We show that expression levels of many critical growth regulators such as Wnt and TGFβ pathway components ...[more]