Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Z
PROVIDER: S-EPMC6878223 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Zhu Zilu Z Shukla Ashima A Ramezani-Rad Parham P Apgar John R JR Rickert Robert C RC
Life science alliance 20191125 6
The PI3K pathway is integral for the germinal center (GC) response. However, the contribution of protein kinase B (AKT) as a PI3K effector in GC B cells remains unknown. Here, we show that mice lacking the AKT1 and AKT2 isoforms in B cells failed to form GCs, which undermined affinity maturation and antibody production in response to immunization. Upon B-cell receptor stimulation, AKT1/2-deficient B cells showed poor survival, reduced proliferation, and impaired mitochondrial and metabolic fitne ...[more]