Dataset Information

Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study.

ABSTRACT: BACKGROUND:The risk for obesity-related disorders is proportional to the visceral region and had been observed to be highly related with impaired renal function. In the current study, we aimed to evaluate renal function impairment, according to sex, age, and different status of metabolic body composition. METHODS:We retrospectively collected from the medical records the basic information and metabolic titers of Chinese adults (13,373 men and 10,175 women) who underwent health checkup from 2013 to 2016. The population was divided into four groups, according to metabolic body composition, including metabolic healthy norms-weight (MHNW), metabolic healthy obesity (MHO), metabolic unhealthy norms-weight (MUNW), and metabolic unhealthy obesity (MUO). The categorical data were compared among the groups and logistic regression analyses were conducted to investigate the association between metabolic body composition status and risk for renal function impairment. RESULTS:Across all ages in both sexes, the odds ratios (OR) for renal function impairment were higher in the MHO, MUNW, and MUO groups than in the MHNW group, except for women <45 years old in the MUNW group. However, after adjustment, the trend was no longer significant in all groups under 45 years old. For individuals >45 years old, the relatively high risk for renal function impairment remained significantly associated with the MUNW group (OR 2.95, 95% CI 2.02-4.30 in men and OR 1.95, 95% CI 1.35-2.82 in women) and MUO group (OR 2.33, 95% CI 1.82-3.00 in men and OR 2.67, 95% CI 2.04-3.48 in women). CONCLUSION:Impaired renal function was independently associated with the status of metabolic obesity. However, the trend was only observed in individuals >45 years old, with significant sex difference.

SUBMITTER: Li WC

PROVIDER: S-EPMC6879116 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study.

Li Wen-Cheng WC Chen Jau-Yuan JY Liu Yu-Ping YP Lee Yi-Yen YY Yeh Wei-Chung WC Yu Wei W Tsao Yu-Chung YC

PloS one 20191126 11

<h4>Background</h4>The risk for obesity-related disorders is proportional to the visceral region and had been observed to be highly related with impaired renal function. In the current study, we aimed to evaluate renal function impairment, according to sex, age, and different status of metabolic body composition.<h4>Methods</h4>We retrospectively collected from the medical records the basic information and metabolic titers of Chinese adults (13,373 men and 10,175 women) who underwent health chec ...[more]

PMID: 31770376

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Dataset Information

Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study.

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Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study.

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