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Biological intratumoral therapy for the high-grade glioma part II: vector- and cell-based therapies and radioimmunotherapy.

ABSTRACT: Management of high-grade gliomas (HGGs) remains a complex challenge with an overall poor prognosis despite aggressive multimodal treatment. New translational research has focused on maximizing tumor cell eradication through improved tumor cell targeting while minimizing collateral systemic side effects. In particular, biological intratumoral therapies have been the focus of novel translational research efforts due to their inherent potential to be both dynamically adaptive and target specific. This two part review will provide an overview of biological intratumoral therapies that have been evaluated in human clinical trials in HGGs, and summarize key advances and remaining challenges in the development of these therapies as a potential new paradigm in the management of HGGs. Part II discusses vector-based therapies, cell-based therapies and radioimmunotherapy.

SUBMITTER: Loya J

PROVIDER: S-EPMC6880300 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Biological intratumoral therapy for the high-grade glioma part II: vector- and cell-based therapies and radioimmunotherapy.

Loya Joshua J Zhang Charlie C Cox Emily E Achrol Achal S AS Kesari Santosh S

CNS oncology 20191121 3

Management of high-grade gliomas (HGGs) remains a complex challenge with an overall poor prognosis despite aggressive multimodal treatment. New translational research has focused on maximizing tumor cell eradication through improved tumor cell targeting while minimizing collateral systemic side effects. In particular, biological intratumoral therapies have been the focus of novel translational research efforts due to their inherent potential to be both dynamically adaptive and target specific. T ...[more]

PMID: 31747784

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Biological intratumoral therapy for the high-grade glioma part I: intratumoral delivery and immunotoxins.

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| S-EPMC6880302 | biostudies-literature

Against the Resilience of High-Grade Gliomas: Gene Therapies (Part II).

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Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity.

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Clinically Explored Virus-Based Therapies for the Treatment of Recurrent High-Grade Glioma in Adults.

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