Ontology highlight
ABSTRACT:
SUBMITTER: Ricklefs F
PROVIDER: S-EPMC4873326 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Ricklefs Franz F Mineo Marco M Rooj Arun K AK Nakano Ichiro I Charest Al A Weissleder Ralph R Breakefield Xandra O XO Chiocca E Antonio EA Godlewski Jakub J Bronisz Agnieszka A
Cancer research 20160324 10
A lack of experimental models of tumor heterogeneity limits our knowledge of the complex subpopulation dynamics within the tumor ecosystem. In high-grade gliomas (HGG), distinct hierarchical cell populations arise from different glioma stem-like cell (GSC) subpopulations. Extracellular vesicles (EV) shed by cells may serve as conduits of genetic and signaling communications; however, little is known about how HGG heterogeneity may impact EV content and activity. In this study, we performed a pro ...[more]