Ontology highlight
ABSTRACT:
SUBMITTER: Balcerak A
PROVIDER: S-EPMC6880882 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Balcerak Anna A Trebinska-Stryjewska Alicja A Wakula Maciej M Chmielarczyk Mateusz M Smietanka Urszula U Rubel Tymon T Konopinski Ryszard R Macech-Klicka Ewelina E Zub Renata R Grzybowska Ewa Anna EA
Molecular biology of the cell 20191023 25
HAX1 protein is involved in the regulation of apoptosis, cell motility and calcium homeostasis. Its overexpression was reported in several tumors, including breast cancer. This study demonstrates that HAX1 has an impact on collective, but not single-cell migration, thus indicating the importance of cell-cell contacts for the HAX1-mediated effect. Accordingly, it was shown that <i>HAX1</i> knockdown affects cell-cell junctions, substrate adhesion, and epithelial cell layer integrity. As demonstra ...[more]