Ontology highlight
ABSTRACT:
SUBMITTER: Wang WY
PROVIDER: S-EPMC6414652 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Wang William Y WY Davidson Christopher D CD Lin Daphne D Baker Brendon M BM
Nature communications 20190312 1
Cells select from a diverse repertoire of migration strategies. Recent developments in tunable biomaterials have helped identify how extracellular matrix properties influence migration, however, many settings lack the fibrous architecture characteristic of native tissues. To investigate migration in fibrous contexts, we independently varied the alignment and stiffness of synthetic 3D fiber matrices and identified two phenotypically distinct migration modes. In contrast to stiff matrices where ce ...[more]