Ontology highlight
ABSTRACT:
SUBMITTER: Anderson CM
PROVIDER: S-EPMC6881100 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Anderson Carryn M CM Lee Christopher M CM Saunders Deborah P DP Curtis Amarinthia A Dunlap Neal N Nangia Chaitali C Lee Arielle S AS Gordon Sharon M SM Kovoor Philip P Arevalo-Araujo Roberto R Bar-Ad Voichita V Peddada Abhinand A Colvett Kyle K Miller Douglas D Jain Anshu K AK Wheeler James J Blakaj Dukagjin D Bonomi Marcelo M Agarwala Sanjiv S SS Garg Madhur M Worden Francis F Holmlund Jon J Brill Jeffrey M JM Downs Matt M Sonis Stephen T ST Katz Sanford S Buatti John M JM
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20191016 34
<h4>Purpose</h4>Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the efficacy and safety of GC4419, a superoxide dismutase mimetic, with placebo to reduce the duration, incidence, and severity of severe OM (SOM).<h4>Patients and methods</h4>A total of 223 patients (from 44 institutions) with locally advanced oral cavity or oropharynx cancer ...[more]