Ontology highlight
ABSTRACT:
SUBMITTER: Flores C
PROVIDER: S-EPMC6881165 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Science advances 20191127 11
In both human and murine systems, we have developed an adoptive cellular therapy platform against medulloblastoma and glioblastoma that uses dendritic cells pulsed with a tumor RNA transcriptome to expand polyclonal tumor-reactive T cells against a plurality of antigens within heterogeneous brain tumors. We demonstrate that peripheral TCR Vβ repertoire analysis after adoptive cellular therapy reveals that effective response to adoptive cellular therapy is concordant with massive in vivo expansio ...[more]