Acute Kidney Injury in the Outpatient Setting Associates with Risk of End-Stage Renal Disease and Death in Patients with CKD.

ABSTRACT: Current acute kidney injury (AKI) diagnostic criteria are restricted to the inpatient setting. We proposed a new AKI diagnostic algorithm for the outpatient setting and evaluate whether outpatient AKI (AKI_OPT) modifies the disease course among patients with chronic kidney disease (CKD) enrolled in the national predialysis registry. AKI_OPT was detected when a 50% increase in serum creatinine level or 35% decline in eGFR was observed in the 180-day period prior to enrollment in the predialysis care program. Outcomes were progression to end-stage renal disease (ESRD) and all-cause mortality. Association analyses were performed using multiple Cox regression and coarsened exact matching (CEM) analysis. Among 6,046 patients, 31.5% (1,905 patients) had developed AKI_OPT within the 180-day period before enrollment. The adjusted hazard ratios of the 1-year and overall risk of ESRD among patients with preceding AKI_OPT compared with those without AKI_OPT were 2.61 (95% CI: 2.15-3.18) and 1.97 (1.72-2.26), respectively. For 1-year and overall risk of all-cause mortality, patients with AKI_OPT had respectively a 141% (95% CI: 89-209%) and 84% (56-117%) higher risk than those without AKI_OPT. This statistical inference remained robust in CEM analysis. We also discovered a complete reversal in the eGFR slope before and after the AKI_OPT from -10.61?±?0.32 to 0.25?±?0.30?mL/min/1.73?m² per year; however, the loss of kidney function is not recovered. The new AKI_OPT diagnostic algorithm provides prognostic insight in patients with CKD.

SUBMITTER: Yeh HC 

PROVIDER: S-EPMC6881443 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature