Ontology highlight
ABSTRACT:
SUBMITTER: Fekri F
PROVIDER: S-EPMC6882852 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Fekri Farnaz F Abousawan John J Bautista Stephen S Orofiamma Laura L Dayam Roya M RM Antonescu Costin N CN Karshafian Raffi R
Scientific reports 20191128 1
Cellular uptake is limiting for the efficacy of many cytotoxic drugs used to treat cancer. Identifying endocytic mechanisms that can be modulated with targeted, clinically-relevant interventions is important to enhance the efficacy of various cancer drugs. We identify that flotillin-dependent endocytosis can be targeted and upregulated by ultrasound and microbubble (USMB) treatments to enhance uptake and efficacy of cancer drugs such as cisplatin. USMB involves targeted ultrasound following admi ...[more]