Dataset Information

Cu(II) and magnetite nanoparticles decorated melamine-functionalized chitosan: A synergistic multifunctional catalyst for sustainable cascade oxidation of benzyl alcohols/Knoevenagel condensation.

ABSTRACT: The uniform decoration of Cu(II) species and magnetic nanoparticles on the melamine-functionalized chitosan afforded a new supramolecular biopolymeric nanocomposite (Cs-Pr-Me-Cu(II)-Fe₃O₄). The morphology, structure, and catalytic activity of the Cs-Pr-Me-Cu(II)-Fe₃O₄ nanocomposite have been systematically investigated. It was found that Cs-Pr-Me-Cu(II)-Fe₃O₄ nanocomposite can smoothly promote environmentally benign oxidation of different benzyl alcohol derivatives by tert-butyl hydroperoxide (TBHP) to their corresponding benzaldehydes and subsequent Knoevenagel condensation with malononitrile, as a multifunctional catalyst. Interestingly, Fe₃O₄ nanoparticles enhance the catalytic activity of Cu(II) species. The corresponding benzylidenemalononitriles were formed in high to excellent yields at ambient pressure and temperature. The heterogeneous Cs-Pr-Me-Cu(II)-Fe₃O₄ catalyst was also very stable with almost no leaching of the Cu(II) species into the reaction medium and could be easily recovered by an external magnet. The recycled Cs-Pr-Me-Cu(II)-Fe₃O₄ was reused at least four times with slight loss of its activity. This is a successful example of the combination of chemo- and bio-drived materials catalysis for mimicing biocatalysis as well as sustainable and one pot multistep synthesis.

SUBMITTER: Alirezvani Z

PROVIDER: S-EPMC6883033 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Cu(II) and magnetite nanoparticles decorated melamine-functionalized chitosan: A synergistic multifunctional catalyst for sustainable cascade oxidation of benzyl alcohols/Knoevenagel condensation.

Alirezvani Zahra Z Dekamin Mohammad G MG Valiey Ehsan E

Scientific reports 20191128 1

The uniform decoration of Cu(II) species and magnetic nanoparticles on the melamine-functionalized chitosan afforded a new supramolecular biopolymeric nanocomposite (Cs-Pr-Me-Cu(II)-Fe3O4). The morphology, structure, and catalytic activity of the Cs-Pr-Me-Cu(II)-Fe3O4 nanocomposite have been systematically investigated. It was found that Cs-Pr-Me-Cu(II)-Fe3O4 nanocomposite can smoothly promote environmentally benign oxidation of d ...[more]

PMID: 31780721

Similar Datasets

Project description:BackgroundMost traditional wound dressings only partially meet the needs of wound healing because of their single function. Patients usually suffer from the increasing cost of treatment and pain resulting from the frequent changing of wound dressings. Herein, we have developed a mutifunctional cryogel to promote bacterial infected wound healing based on a biocompatible polysaccharide.MethodsThe multifunctional cryogel is made up of a compositive scaffold of chitosan (CS), gelatin (Gel) and tannic acid (TA) and in situ formed silver nanoparticles (Ag NPs). A liver bleeding rat model was used to evaluate the dynamic hemostasis performance of the various cryogels. In order to evaluate the antibacterial properties of the prepared cryogels, gram-positive bacterium Staphylococcus aureus (S. aureus) and gram-negative bacterium Escherichia coli (E. coli) were cultured with the cryogels for 12 h. Meanwhile, S. aureus was introduced to cause bacterial infection in vivo. After treatment for 2 days, the exudates from wound sites were dipped for bacterial colony culture. Subsequently, the anti-inflammatory effect of the various cryogels was evaluated by western blotting and enzyme-linked immunosorbent assay. Finally, full-thickness skin defect models on the back of SD rats were established to assess the wound healing performances of the cryogels.ResultsDue to its porous structure, the multifunctional cryogel showed fast liver hemostasis. The introduced Ag NPs endowed the cryogel with an antibacterial efficiency of >99.9% against both S. aureus and E. coli. Benefited from the polyphenol groups of TA, the cryogel could inhibit nuclear factor-κB nuclear translocation and down-regulate inflammatory cytokines for an anti-inflammatory effect. Meanwhile, excessive reactive oxygen species could also be scavenged effectively. Despite the presence of Ag NPs, the cryogel did not show cytotoxicity and hemolysis. Moreover, in vivo experiments demonstrated that the biocompatible cryogel displayed effective bacterial disinfection and accelerated wound healing.ConclusionsThe multifunctional cryogel, with fast hemostasis, antibacterial and anti-inflammation properties and the ability to promote cell proliferation could be widely applied as a wound dressing for bacterial infected wound healing.

Dataset Information

Cu(II) and magnetite nanoparticles decorated melamine-functionalized chitosan: A synergistic multifunctional catalyst for sustainable cascade oxidation of benzyl alcohols/Knoevenagel condensation.

Publications

Cu(II) and magnetite nanoparticles decorated melamine-functionalized chitosan: A synergistic multifunctional catalyst for sustainable cascade oxidation of benzyl alcohols/Knoevenagel condensation.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets