Ontology highlight
ABSTRACT:
SUBMITTER: Sprung J
PROVIDER: S-EPMC6883493 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sprung Juraj J Kruthiventi S Chandralekha SC Warner David O DO Knopman David S DS Petersen Ronald C RC Mielke Michelle M MM Jack Clifford R CR Graff-Radford Jonathan J Martin David P DP Hanson Andrew C AC Schroeder Darrell R DR Przybelski Scott A SA Schulte Phillip J PJ Weingarten Toby N TN Vemuri Prashanthi P
British journal of anaesthesia 20191003 6
<h4>Background</h4>Preclinical studies suggest that exposure to general anaesthesia (GA) could cause neurodegeneration consistent with Alzheimer's disease (AD) pathology. Brain magnetic resonance imaging (MRI) is useful to study structural brain changes. We tested the hypothesis that exposure to surgery with GA (surgery/GA) is associated with greater cortical thinning and increased frequency of white matter lesions.<h4>Methods</h4>This is a cross-sectional analysis of 70-91-yr-old participants e ...[more]