Ontology highlight
ABSTRACT:
SUBMITTER: Subramanian A
PROVIDER: S-EPMC6884507 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Nature communications 20191129 1
Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but assessing their consistency and reproducibility across iPSC lines, and reducing the generation of off-target cells remain an open challenge. Here, we profile four human iPSC lines for a total of 450,118 single cells to show how organoid composition and development are comparable to human fetal and adult kidneys. Although cell classes are largely reproducible across time points, protocols, and replicates, we de ...[more]