Ontology highlight
ABSTRACT:
SUBMITTER: Hutinet G
PROVIDER: S-EPMC6884629 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Hutinet Geoffrey G Kot Witold W Cui Liang L Hillebrand Roman R Balamkundu Seetharamsingh S Gnanakalai Shanmugavel S Neelakandan Ramesh R Carstens Alexander B AB Fa Lui Chuan C Tremblay Denise D Jacobs-Sera Deborah D Sassanfar Mandana M Lee Yan-Jiun YJ Weigele Peter P Moineau Sylvain S Hatfull Graham F GF Dedon Peter C PC Hansen Lars H LH de Crécy-Lagard Valérie V
Nature communications 20191129 1
Genome modifications are central components of the continuous arms race between viruses and their hosts. The archaeosine base (G<sup>+</sup>), which was thought to be found only in archaeal tRNAs, was recently detected in genomic DNA of Enterobacteria phage 9g and was proposed to protect phage DNA from a wide variety of restriction enzymes. In this study, we identify three additional 2'-deoxy-7-deazaguanine modifications, which are all intermediates of the same pathway, in viruses: 2'-deoxy-7-am ...[more]