Ontology highlight
ABSTRACT:
SUBMITTER: Floudas CS
PROVIDER: S-EPMC6884678 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Floudas Charalampos S CS Brar Gagandeep G Mabry-Hrones Donna D Duffy Austin G AG Wood Bradford B Levy Elliot E Krishnasamy Venkatesh V Fioravanti Suzanne S Bonilla Cecilia M CM Walker Melissa M Morelli Maria Pia MP Kleiner David E DE Steinberg Seth M SM Figg William D WD Greten Tim F TF Xie Changqing C
Clinical colorectal cancer 20190702 4
<h4>Background</h4>The prognosis of metastatic colorectal cancer (mCRC) is poor. We assessed the feasibility, safety, and efficacy of the anti-programmed cell death 1 fusion protein AMP-224 in combination with low-dose cyclophosphamide and stereotactic body radiation (SBRT) treatment in patients with mCRC refractory to standard chemotherapy.<h4>Patients and methods</h4>Fifteen patients were enrolled. Six received SBRT 8 Gy on day 0 (dose level 1), whereas 9 received 8 Gy on days -2 to day 0. All ...[more]