Limited predictive value of TFAM in mitochondrial biogenesis.
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ABSTRACT:
SUBMITTER: Kozhukhar N
PROVIDER: S-EPMC6885536 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Limited predictive value of TFAM in mitochondrial biogenesis.
Kozhukhar Natalya N Alexeyev Mikhail F MF
Mitochondrion 20190813
Mitochondrial transcription factor A (TFAM) plays an important role in mitochondrial DNA (mtDNA) transcription and replication. In some experimental settings, TFAM expression parallels parameters of mitochondrial biogenesis, which led to a widespread acceptance of TFAM as marker of mitochondrial biogenesis. We modulated TFAM expression in several experimental systems and observed that it fails to consistently parallel mtDNA copy number and expression of mtDNA-encoded polypeptides. We suggest tha ...[more]
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