Ontology highlight
ABSTRACT:
SUBMITTER: Dong Q
PROVIDER: S-EPMC6886123 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Dong Qiongzhu Q Du Yi Y Li Hui H Liu Chunxiao C Wei Yongkun Y Chen Mei-Kuang MK Zhao Xixi X Chu Yu-Yi YY Qiu Yufan Y Qin Lunxiu L Yamaguchi Hirohito H Hung Mien-Chie MC
Cancer research 20181220 4
PARP1 inhibitors (PARPi) are currently used in the clinic for the treatment of ovarian and breast cancers, yet their therapeutic efficacy against hepatocellular carcinoma (HCC) has been disappointing. To ensure therapeutic efficacy of PARPi against HCC, a disease often diagnosed at intermediate to advanced stages with no effective treatment options, it is critical to identify not only biomarkers to predict PARPi resistance but also rational treatments to overcome this. Here, we report that a het ...[more]