Acidosis and proteolysis in the tumor microenvironment.
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ABSTRACT:
SUBMITTER: Ji K
PROVIDER: S-EPMC6886241 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Acidosis and proteolysis in the tumor microenvironment.
Ji Kyungmin K Mayernik Linda L Moin Kamiar K Sloane Bonnie F BF
Cancer metastasis reviews 20190601 1-2
The glycolytic phenotype of the Warburg effect is associated with acidification of the tumor microenvironment. In this review, we describe how acidification of the tumor microenvironment may increase the invasive and degradative phenotype of cancer cells. As a template of an extracellular acidic microenvironment that is linked to proteolysis, we use the resorptive pit formed between osteoclasts and bone. We describe similar changes that have been observed in cancer cells in response to an acidic ...[more]
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