Ontology highlight
ABSTRACT:
SUBMITTER: Wellington S
PROVIDER: S-EPMC6886523 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Wellington Samantha S Nag Partha P PP Michalska Karolina K Johnston Stephen E SE Jedrzejczak Robert P RP Kaushik Virendar K VK Clatworthy Anne E AE Siddiqi Noman N McCarren Patrick P Bajrami Besnik B Maltseva Natalia I NI Combs Senya S Fisher Stewart L SL Joachimiak Andrzej A Schreiber Stuart L SL Hung Deborah T DT
Nature chemical biology 20170703 9
New antibiotics with novel targets are greatly needed. Bacteria have numerous essential functions, but only a small fraction of such processes-primarily those involved in macromolecular synthesis-are inhibited by current drugs. Targeting metabolic enzymes has been the focus of recent interest, but effective inhibitors have been difficult to identify. We describe a synthetic azetidine derivative, BRD4592, that kills Mycobacterium tuberculosis (Mtb) through allosteric inhibition of tryptophan synt ...[more]