Ontology highlight
ABSTRACT:
SUBMITTER: Amgalan D
PROVIDER: S-EPMC7413180 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nature cancer 20200302 3
Doxorubicin remains an essential component of many cancer regimens, but its use is limited by lethal cardiomyopathy, which has been difficult to target, owing to pleiotropic mechanisms leading to apoptotic and necrotic cardiac cell death. Here we show that BAX is rate-limiting in doxorubicin-induced cardiomyopathy and identify a small-molecule BAX inhibitor that blocks both apoptosis and necrosis to prevent this syndrome. By allosterically inhibiting BAX conformational activation, this compound ...[more]