Unknown

Dataset Information

0

Cooking shapes the structure and function of the gut microbiome.


ABSTRACT: Diet is a critical determinant of variation in gut microbial structure and function, outweighing even host genetics1-3. Numerous microbiome studies have compared diets with divergent ingredients1-5, but the everyday practice of cooking remains understudied. Here, we show that a plant diet served raw versus cooked reshapes the murine gut microbiome, with effects attributable to improvements in starch digestibility and degradation of plant-derived compounds. Shifts in the gut microbiota modulated host energy status, applied across multiple starch-rich plants, and were detectable in humans. Thus, diet-driven host-microbial interactions depend on the food as well as its form. Because cooking is human-specific, ubiquitous and ancient6,7, our results prompt the hypothesis that humans and our microbiomes co-evolved under unique cooking-related pressures.

SUBMITTER: Carmody RN 

PROVIDER: S-EPMC6886678 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


Diet is a critical determinant of variation in gut microbial structure and function, outweighing even host genetics<sup>1-3</sup>. Numerous microbiome studies have compared diets with divergent ingredients<sup>1-5</sup>, but the everyday practice of cooking remains understudied. Here, we show that a plant diet served raw versus cooked reshapes the murine gut microbiome, with effects attributable to improvements in starch digestibility and degradation of plant-derived compounds. Shifts in the gut  ...[more]

Similar Datasets

| S-EPMC5597826 | biostudies-literature
| S-EPMC4550057 | biostudies-literature
2021-02-25 | GSE150091 | GEO
| S-EPMC9014604 | biostudies-literature
| S-EPMC8105323 | biostudies-literature
| S-EPMC5778015 | biostudies-literature
| S-EPMC5345693 | biostudies-literature
| S-EPMC8326577 | biostudies-literature
| S-EPMC8383385 | biostudies-literature
| S-EPMC5956147 | biostudies-literature